Running is an innate ability of human beings, and it is both simple and not simple. Running requires the coordination of the nervous, musculoskeletal, and cardiovascular systems and three major tissue and organ systems that are related to exercise. When the body has problems, we cannot just simply follow the rules of “when the head hurts, we treat the head; when the foot hurts, we treat the foot.” Our body is a vast interconnected, influenced and interacted system, therefore, both runners and medical workers should have a holistic view of the body. Dialectically consider the cause, development, and prospects of the injury, catch the root of the illness, and find the remedies.